Product Name: Clotrimazole Synonyms: (2-Chlorophenyl)diphenyl-1-imidazolylmethane;(Chlorotrityl)imidazole;1-((2-chlorophenyl)diphenylmethyl)-1h-imidazol;1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole;1-(o-chloro-alpha,alpha-diphenylbenzyl)-imidazol;1-[(2-chlorophenyl)diphenylmethyl]-1h-imidazol;1-[alpha-(2-chlorophenyl)benzhydryl]imidazole;1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]- CAS: 23593-75-1 MF: C22H17ClN2 MW: 344.84 EINECS: 245-764-8 Chemical Properties It is white powder or colorless crystalline powder. It has a melting point of 147-149 ºC. It is soluble in ethanol, acetone, and chloroform, but almost insoluble in water. It is odorless, tasteless and subject to rapid decomposition in an acid solution. Clotrimazole hydrochloride has a m.p. of 159 ºC. Production method It can be obtained from o-benzoic acid via esterification, addition, hydrolysis, chlorination, and condensation. It may also be obtained by chlorination of o-chlorotoluene into o-chloro benzotrichloride, which, in the presence of aluminum chloride, has condensation reaction with benzene to generate diphenyl - (2-chlorophenyl) methyl chloride, which finally has condensation reaction with imidazole to obtain clotrimazole. Chemical Properties Crystalline Usage Clotrimazole is an antifungal agent.
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